News
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New paper published! Dissecting gap junction circuits in C. elegans.
See the paper here!
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Picower Retreat!
We attended the department-wide retreat in Newport, RI! The event was from June 6-7.
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Flavell Lab Hosts Happy Hour!
Making an introduction into the Picower community and a chance to meet our friends and neighbors!
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Lab Renovations Complete!
Pictures of the finished product!
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Lab Renovations Nearing Completion!
Check out these pictures of our lab coming together!
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Lab Opens for Business!
A few pictures of our empty lab!
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Distinct mechanisms underlie quiescence during two Caenorhabditis elegans sleep-like states
Electrophysiological recordings have enabled identification of physiologically distinct yet behaviorally similar states of mammalian sleep. In contrast, sleep in nonmammals has generally been identified behaviorally and therefore regarded as a physiologically uniform state characterized by quiescence of feeding and locomotion, reduced responsiveness, and rapid reversibility. The nematode Caenorhabditis elegans displays sleep-like quiescent behavior under two…
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A circuit for gradient climbing in C. elegans chemotaxis
Animals have a remarkable ability to track dynamic sensory information. For example, the nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold concentration range. Here, we relate neuronal properties, circuit implementation, and behavioral strategies underlying this robust navigation. Diacetyl responses in AWA olfactory neurons are concentration and history dependent; AWA integrates over…
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Feedback from network states generates variability in a probabilistic olfactory circuit
Variability is a prominent feature of behavior and is an active element of certain behavioral strategies. To understand how neuronal circuits control variability, we examined the propagation of sensory information in a chemotaxis circuit of C. elegans where discrete sensory inputs can drive a probabilistic behavioral response. Olfactory neurons respond to odor stimuli with rapid…
